Endocrine Abstracts

Beta-cell failure is central to the pathogenenis of both type 1 and type 2 diabetes mellitus. In type 1 diabetes immune-mediated beta-cell destruction takes place, whereas in type 2 diabetes metabolic factors are believed to induce progressively deteriation of beta-cell function and finally reduced beta-cell mass. The proinflammatory cytokine interleukin-1 could be a mediator of the beta-cell failure in both diseases: In type 1 diabetes by the secretion from actived macrophage...